This document describes one reference method, broth micro-dilution, for determination of MICs. The MIC can be a guide for the clinician, and reflects the activity of the drug under the described test conditions, by taking into account other factors, such as drug pharmacology, pharmacokinetics, or bacterial resistance mechanisms. This allows categorisation of bacteria as "susceptible" (S), "intermediate" (I), or "resistant" (R). In addition, MIC distributions can be used to define wild type or non-wild type bacterial populations. Although clinical interpretation of the MIC value is beyond the scope of this document, modifications of the basic method are required for certain antimicrobial agent - bacteria combinations to facilitate clinical interpretation. These modifications are included in a separate annex of this document. It is necessary to compare other susceptibility testing methods (e.g. disc diffusion or diagnostic test devices) with this reference method for validation, in order to ensure comparable and reliable results.
Status: PublishedPublication date: 2019-06
Corrected version (en): 2019-12
Corrected version (fr): 2019-12
Edition: 2Number of pages: 19
Technical Committee: ISO/TC 212 Clinical laboratory testing and in vitro diagnostic test systems
- ICS :
- 11.100.20 Biological evaluation of medical devices
This standard contributes to the following Sustainable Development Goal:
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ISO 20776-1:2019Stage: 60.60
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